Home
Search results “Natural product syntheses”
4/1/17 Timothy Newhouse - Not for Fools: Organic Synthesis of Natural Products
 
47:21
Speaker: Timothy Newhouse (Yale Chemistry) Making the materials and therapeutics of the future, synthetic chemists synthesize and discover new molecules by twisting bonds and stereocenters at their will. Come join us to learn from Professor Tim Newhouse how the real Walter Whites of the world manipulate organic molecules to get rich. Science Saturdays is a special lecture series designed for families that brings the excitement of research and the passion of scientists to the community. Each event involves a lecture by a Yale professor and hands-on science demonstrations run by Yale College students. Bring the whole family! For more event information, go to: www.yale.edu/scienceoutreach.
Views: 1244 YaleUniversity
Total Synthesis of Reserpine - R.B. Woodward
 
09:00
Please consider supporting the channel on Patreon! https://www.patreon.com/SupremeScience Dr. Andrew Grant covers the Total Synthesis of Reserpine as described R.B. Woodward. Enjoy! Music by the wonderful Nathaniel Schroeder. https://soundcloud.com/drschroeder © ® The Nobel Foundation.
Views: 20173 Supreme Science
100 Years of Natural Product Synthesis Mobile
 
15:01
History of Organic Chemistry at the Helsinki University of Technology Chemistry Deparment starting form Komppa to 2003
Views: 356 Ari Koskinen
38. Review: Synthesis of Cortisone
 
52:09
Freshman Organic Chemistry II (CHEM 125B) Discoverers of the structure and biological activity of steroid hormones won seven Nobel Prizes between 1927 and 1975. Studying the steps involved in Woodward's 1951 "total" synthesis of cortisone provides a review of the organic reactions covered this semester. Many steps involved novel insights, others were based on lore from previous work In the area. The overall yield of such sequential syntheses is typically much lower than that of convergent syntheses. Practical syntheses of cortisone were based on modification of related steroids readily available from nature. Milestones in total synthesis include both purely intellectual work with natural products and commercially important synthesis of designed pharmaceuticals. The course ends with thanks to those, young and old, who have taught us all. 00:00 - Chapter 1. Steroids and the Medicinal Activity of Cortisone 07:43 - Chapter 2. Woodward's Total Synthesis of Cortisone 33:27 - Chapter 3. Practical Synthesis of Cortisone 38:59 - Chapter 4. Some Milestones in Organic Synthesis 44:59 - Chapter 5. Thanks to Teachers, Colleagues, Family, and Students Complete course materials are available at the Open Yale Courses website: http://oyc.yale.edu This course was recorded in Spring 2011.
Views: 9648 YaleCourses
Search for and synthesis of natural organic compounds with unique structures and functions
 
04:07
Nakata-Saikawa Laboratory, Department of Applied Chemistry, Faculty of Science and Technology, Keio University Search for and synthesis of natural organic compounds with unique structures and functions
Views: 3528 ikinamo
The Art of Chemical Synthesis
 
03:45
The Center for Selective C-H Functionalization (CCHF) is leading a paradigm shift in the art of organic synthesis by bringing together experts from across a broad range of chemical disciplines. This collaborative network has an equally broad geographical distribution, with institutes from across the United States. http://nsf-cchf.com
Views: 16697 Emory University
Synthesis of Colouring Agent (Natural Products)
 
07:32
This video, was once distributed for community service schemes in Gowa Regency South Sulawesi (Sept 9, 2015), is now dedicated for undergraduate students of Pharmacy UNHAS to uplift their out-of-textbook-knowledge.
Views: 324 Yusnita Rifai
How to Design a Total Synthesis
 
18:31
In this video, I include footage from a lecture I delivered teaching students the basic principles of how to design a total synthesis of a molecule, focusing on retrosynthetic analysis.
Views: 16723 Mike Christiansen
Total Synthesis of Longifolene
 
08:57
In this video you will find a brief overview of the total synthesis of longifolene. Each reaction is discussed in detail. Youtube Channel (Hindi) - https://www.youtube.com/channel/UCmIchtf7_PvcAOfT5p5f6eQ Unacademy - https://unacademy.com/user/Sethi Disclaimer The information provided on this channel is a public service with the understanding that Gate Chemistry makes no warranties, either expressed or implied, related to completeness, accuracy, reliability or suitability of the information. The channel disclaims liability for errors and omissions that may have crept in its content.
Views: 1854 Gate chemistry
Lead generation
 
36:29
Part of an undergraduate lecture series "Clinical Drug Development". Covers the screening of compounds to search for actives, hits and then leads. 1:57 Definitions 4:00 Steps in lead generation 6:33 Desirable properties of a lead 8:16 Where do compounds come from? 10:11 Natural products 11:47 Combinatorial chemistry 15:10 Mix and split synthesis 16:14 Multiple parallel syntheses 17:18 Numbers of compoiunds for screening 18:55 Chemical diversity 21:27 Options for lead generation 23:59 Rational design 26:47 Empirical screening 29:39 High throughput screening 32:04 Assay and screen design 33:02 Screen validation 34:26 Compound screening
Views: 11241 Professor G
Total synthesis of Azumamides and analogs
 
01:52
Jesper Villadsen presents his PhD project
Views: 768 DTUdk
Chemistry Is All About Perspective - Twistane Total Synthesis
 
05:09
Please consider supporting the channel on Patreon! https://www.patreon.com/SupremeScience In this video, Dr. Andrew Grant explores how looking at target molecules in different light, give new insight into Organic Synthetic Strategies. He achieves this by tackling the total synthesis and history of a unique molecule, Twistane. Enjoy! Music by the wonderful Nathaniel Schroeder. https://soundcloud.com/drschroeder
Views: 4448 Supreme Science
Total Synthesis of Ginkgolide B
 
03:16
Update!! Finally, I have made a video of Ginkgolide B with commentary. You can check out part 1 here: https://youtu.be/V76kv4hO3WQ and part two here: https://youtu.be/Ish0ld3Oi0o Part one of the Total Synthesis of Ginkgolide B Music by Kevin MacLeod (The Descent)
Views: 2145 OrganicChemistOnCall
Cocaine synthesis (FENDERSON5555)
 
04:25
Fenderson looks at the underlying mechanisms of the synthesis of cocaine, the well known tropane stimulant.
Views: 6610 Jacob Tierney
Legal high from moss better than medical cannabis? History, Biology, Synthesis of THC, CBD & PET
 
28:56
Hey guys, I'm back with another video! This time, we will cover the basics of cannabinoids. We'll discuss the history, biochemistry, pharmacology and total synthesis of these highly useful natural products. Recent research is used as an example of the importance and potential of cannabinoids in medicine. This video does not endorse the preparation of illegal substances. No detailed steps or procedures for syntheses of illegal drugs are discussed. I hope it's clear that here we focus on fascinating aspects of science and on the potential that compounds have in improving the lives of patients. 00:00 Introduction of medical cannabinoids; Applications of cannabidiol (CBD) and tetrahydrocannabinol (THC) for treatment of epilepsy and other conditions; Introduction of legal high of liverwort 04:35 History and Isolation of THC; Discovery of the endocannabinoid system, endocannabinoid receptors (CB1 and CB2) and endocannabinoids anandamide and arachidonylglyceride; CB1 antagonists as anti-obesity drugs; Total synthesis of THC and CBD by Raphael Mechoulam at the Weizmann Institute 15:18 Can you get legally high from moss or liverwort? Summary of pharmacological results from the key paper, based on work of Professor Gertsch and co-workers at the University of Bern; Tetrad test, Prostaglandins; Implications for medicinal applications 21:32 Organic synthesis and two total syntheses of cis-perrottetine by Professor Carreira at ETH Zürich (2018) and Professor Kim at Seoul University (2008); Discussion of key steps and synthetic strategies and reaction mechanisms 28:17 Closing remarks Mechoulam interview/documentary: - The Scientist (2015): https://www.youtube.com/watch?v=fu6FhJIyTEc Liverwort paper: - Uncovering the psychoactivity of a cannabinoid from liverworts associated with a legal high (Science Advances 2018, 4, 2166): http://advances.sciencemag.org/content/4/10/eaat2166 Some recommended books on organic synthesis: - Clayden, Greeves, Warren; Organic Chemistry (basic organic chemistry knowledge) - Wyatt, Warren; Organic Synthesis: The Disconnection Approach (excellent introduction to retrosynthesis) - Kurti, Czako; Strategic Applications of Named Reactions in Organic Synthesis (extensive toolkit of reactions and applications thereof with common conditions) - Nicolaou et al; Classics in Total Synthesis 1-3 (the ultimate total synthesis trilogy) - Nicolaou; Molecules That Changed the World (the world's most important molecules and their impact on everyday life)
Views: 2085 Total Synthesis
Saxitoxin: CIA Chemical Weapons, Biochemistry and Total Synthesis (Kishi, Jacobi, Du Bois)
 
12:10
Long time no see! I hope you all have been doing better than me in my army bootcamp. This video deals with the history and use of the marine natural product saxitoxin as a chemical weapon, its biochemistry and most importantly, strategies towards its total synthesis. I hope to rejuvenate this channel and make more videos in the future, so please show your support and like & subscribe them. If you have any suggestions on what I should talk about next, the format or difficulty level of the videos or general tips on how to improve, share them with me in the comments. 00:00 Some comments on what I've been up to 00:58 History of saxitoxin and it's use in CIA operations 02:34 Medicinal background saxitoxin (paralytic shellfish poisoning, PSP) and short overview of mechanism of action (sodium channel blocker) 05:39 Retrosynthesis and strategy employed by Yoshito Kishi in 1977: Oldschool organic chemistry and electrocyclizations 07:42 Retrosynthesis and strategy employed by Peter Jacobi in 1984: Dipolar azomethine ylide cycloadditions and radical chemistry 09:37 Retrosynthesis and strategy employed by Du Bois in 2006: Modern C-H functionalization and oxidations References: Kishi: https://pubs.acs.org/doi/abs/10.1021/ja00450a079 Jacobi: https://pubs.acs.org/doi/abs/10.1021/ja00331a032 Du Bois: https://pubs.acs.org/doi/abs/10.1021/ja071501o Some recommended books on organic synthesis: - Clayden, Greeves, Warren; Organic Chemistry (basic organic chemistry knowledge) - Wyatt, Warren; Organic Synthesis: The Disconnection Approach (excellent introduction to retrosynthesis) - Kurti, Czako; Strategic Applications of Named Reactions in Organic Synthesis (extensive toolkit of reactions and applications thereof with common conditions) - Nicolaou et al; Classics in Total Synthesis 1-3 (the ultimate total synthesis trilogy) - Nicolaou; Molecules That Changed the World (the world's most important molecules and their impact on everyday life)
Views: 888 Total Synthesis
Organic Chemistry Walkthrough Steroid Synthesis: History, Retrosynthetic Strategies, Mechanisms
 
07:37
In this video we will talk about the total synthesis of steroid hormones in the early 20th century. After an introduction into the history of steroids and challenges with steroid and natural product isolation, we will go through the retrosynthetic analysis Welcome to this channel around the topic of organic synthesis. This is not an experimental channel showcasing chemical experiments but rather will deal with theoretical discussions of syntheses of important chemicals and interesting natural products. If you are not familiar with organic chemistry, do not expect to understand everything I'm talking about. Please consult the literature, the myriad of youtube videos about basic chemistry or just Google. Some recommended books on organic synthesis: - Clayden, Greeves, Warren; Organic Chemistry (basic organic chemistry knowledge) - Wyatt, Warren; Organic Synthesis: The Disconnection Approach (excellent introduction to retrosynthesis) - Kurti, Czako; Strategic Applications of Named Reactions in Organic Synthesis (extensive toolkit of reactions and applications thereof with common conditions) - Nicolaou et al; Classics in Total Synthesis 1-3 (the ultimate total synthesis trilogy) - Nicolaou; Molecules That Changed the World (the world's most important molecules and their impact on everyday life)
Views: 794 Total Synthesis
Synthesis of Lysergic Acid (LSD Precursor): History, Strategies, Mechanisms (Hofmann, Woodward)
 
18:48
Please excuse some slight audio pops; I'll keep in mind to keep the mic further away next time. Welcome to this channel around the topic of organic synthesis. This is not an experimental channel showcasing chemical experiments but rather will deal with theoretical discussions of syntheses of important chemicals and interesting natural products. If you are not familiar with organic chemistry, do not expect to understand everything I'm talking about. Please consult the literature, the myriad of youtube videos about basic chemistry or just Google. In this first video, we will cover the history of lysergic acid, a LSD precursor, its first total synthesis and a modern approach (with increasing difficulty). I threw in some sidenotes and anecdotes to make the material slightly less dry. 00:00 Introduction about the significance of lysergic acid derivatives and importance of natural products 00:49 Overview 02:09 History preceding the synthesis of lysergic acid about the work of Albert Hofmann at Sandoz (first semisynthesis) 04:12 First total synthesis by chemists at Lilly & Nobel laureate Robert Burns Woodward. This synthesis employs reactions encountered at in the first two years at an undergrad level. 12:40 Modern approach by Prof. Ohno at Kyoto University. This contemporary synthesis relies on organometallic chemistry and more advanced retrosynthetic disconnections. This part contains a short discussion of reaction mechanism. 18:10 Closing comments Tell me whether I should continue doing such videos and if so, whether I should focus on "easy" approaches or more advanced ones (or make two types of videos and do both of them). Subscribe and like this video if you want to show your support. Albert Hofmann's notes: http://www.psychedelic-library.org/hofmann.htm Some recommended books on organic synthesis: - Clayden, Greeves, Warren; Organic Chemistry (basic organic chemistry knowledge) - Wyatt, Warren; Organic Synthesis: The Disconnection Approach (excellent introduction to retrosynthesis) - Kurti, Czako; Strategic Applications of Named Reactions in Organic Synthesis (extensive toolkit of reactions and applications thereof with common conditions) - Nicolaou et al; Classics in Total Synthesis 1-3 (the ultimate total synthesis trilogy) - Nicolaou; Molecules That Changed the World (the world's most important molecules and their impact on everyday life)
Views: 15017 Total Synthesis
3JohnWood
 
42:47
John Wood (Baylor) Recent Progress in the Synthesis of Complex Natural Products - Phomoidride D Part of the Harry Wasserman Memorial Symposium at http://chem.yale.edu/HHW
Views: 917 Mike McBride
What IS Organic Synthesis?
 
02:23
Please consider supporting the channel on Patreon! https://www.patreon.com/SupremeScience What is Organic Synthesis, and what is involved? - As Fast as Possible. Enjoy! Music by the wonderful Nathaniel Schroeder. https://soundcloud.com/drschroeder
Views: 10664 Supreme Science
Organic Electrolytic Synthesis
 
03:46
The Nishiyama Group is studying the synthesis of natural organic compounds using electrical energy. The aim is to synthesize compounds that are useful in medicine and other fields, and to enable environmentally friendly organic synthesis. Q: Our aim is to actually synthesize biologically active organic compounds that occur in nature. There are a wide variety of such compounds, ranging from quite complex to very simple. In particular, a feature of our research is that were using electrochemistry, or electrolysis, for environmentally friendly organic synthesis. Chemical synthesis using electrochemistry and electrolysis can be used to induce only the reactions needed, without producing toxic substances. Consequently, it is currently topical as a means of environmentally friendly chemical synthesis. The Nishiyama Group is breaking new ground internationally, through original organic electrolysis reactions using phenols. QOne current environmental problem is waste products that are organic halogen compounds. As these contain halogens such as chlorine or bromine, they are toxic, and they dont naturally decompose. But electrolysis can be used to remove the halogens.A feature of our research is that we synthesize organic compounds based on phenols. Benzene is easy to polymerize. But if you combine just two benzene rings,please clarify part about ether, or link benzene rings directly, then those compounds can be used, for example, to synthesize a chain of amino acids, which is strongly biologically active. So were doing quite original research on phenol chemistry, using electrochemistry for synthesis, as I mentioned earlier. For pharmaceuticals manufactured by organic synthesis, safety testing is extremely important. It can take over a decade to produce a single drug. Organic electrolysis reactions, which do not use toxic substances, are expected to be very safe, and to enable much faster development. For such research, the Nishiyama Group uses a special system to develop man-made biologically active substances that are more effective than natural organic compounds. QIn our study meetings, we have one team that makes the target substances using electrochemistry, and another team that makes complex compounds using standard chemical synthesis. The two teams can complement each other by bringing together their new discoveries and new technologies. For example, weve had several cases where standard chemical synthesis alone doesnt work, but electrochemistry can be used to find a more effective reaction at once. In that sense, we aim to achieve complete syntheses through both teams helping each other.
Institute of Heavy Organic Synthesis "Blachownia", Kedzierzy-Kozle, Poland (2,40 min version)
 
02:40
The Institute of Heavy Organic Synthesis "Blachownia" (Polish abbreviation - ICSO) is an R&D centre working within the field of organic chemistry. Since 1952 it has been a successful partner for both domestic and foreign organizations developing, implementing and improving chemical processes, production and sale of commodity chemicals. ICSO belongs to the top research units in Poland, which is proved by the category A, granted to ICSO by the Committee for Evaluation of Scientific Units. ICSO carries on R&D and implementation works within the scope of chemical sciences, performs chemical research, tests and analyses. The competence and experience of ICSO is proved by numerous publications, patents and commercial implementations.
Views: 345 ICSO Blachownia
Lisa Marcaurelle - Diversity Oriented Synthesis for Discovery of Novel Therapeutics
 
54:29
Watch on LabRoots at http://labroots.com/webcast/id/612 Recent evidence demonstrating the importance of structural complexity in advancing compounds to the clinic points to the need for enhancing small molecule screening collections with sp3-rich compounds. The development of diversity-oriented synthesis (DOS) strategies for accessing libraries of sp3-rich compounds containing one or more stereogenic centers will be presented, focusing on library synthesis efforts at H3 Biomedicine as well as previous work at the Broad Institute. The DOS libraries which have been created, span a broad range of molecular frameworks, including macrocycles and medium-sized rings, as well as fused-, bridged- and spirocyclic- ring systems. Preliminary results of high-throughput screening of the H3 compound collection will be discussed, with an emphasis on the identification of novel modulators of pre-mRNA splicing.
Views: 534 LabRoots
Warfarin Synthesis
 
04:11
Views: 1348 Yeng X
Synthesis Organic Compound CHEM Study
 
21:26
Synthesis Organic Compound 2nd Edition CHEM Study The Chemical Education Material Study, better known as CHEM Study, was developed in the early 1960s at U.C. Berkeley's College of Chemistry, Lawrence Hall of Science, and Harvey Mudd College, and continued at the Lawrence Hall of Science through the 1980s. The textbook was written by Glenn T. Seaborg in the early 1960s.
Organic Synthesis of Some Commercially-Available Heterocyclic Drugs
 
15:34
Heterocycles is one of my favorite subjects! In this lecture, Dr. KP works through syntheses of a few medicinal heterocyclic drug molecules to chat about interesting mechanisms involving heterocyclic compounds. Synthetic routes are from: Vardanyan, Ruben, and Victor Hruby. Synthesis of essential drugs. Elsevier, 2006.
Views: 705 Molecular Memory
Microwave-assisted organic synthesis is routinely used by Enamine chemists
 
01:43
Microwave-assisted synthesis has been successfully used by Enamine chemists to conduct various types of organic reactions, including heterocyclizations, arylations, couplings etc. to synthesize building blocks for medicinal chemistry applications.
Views: 5762 EnamineStore
Dr. Yang, Total Synthesis Complex Natural Anti-cancer compound Taxol, Structure Modification lab.
 
01:10
AZ Nature Art (www.aznpbio.com) ​9285 Dowdy Drive, Suite 103 San Diego, CA 92126 [email protected]; Tel: 360-464-3767 What We Can Do: Authentic identification of ethnomedicinal plants associated with common names, folk and historic uses, scientific definitions, description, likely alterations and synonyms Geographic distribution and abundance analysis Biological study and Efficacy review Raw material evaluation and sourcing (vendor audit and price investigation, available ingredient and extract purity, strength, composition, active compounds and content range) Comparison and selection of functional plants and ingredients for product formulation Safety evaluation including acute and chronic toxicities, LD50, effects on infants and reproductive organs Irritation and allergy assesment Dosage range suggestion Novelty assessment and patent claims construction Assessment and prediction of oral availability and tissue distribution Quality control method design (UV, HPLC, TLC, HPTLC, GC or GC/MS, organic solvent residues, microbial, heavy metals, and pesticides in standardized extract, compound and ingredient) Manufacturing methods We also supply herbs, raw materials, authentic extracts and cutting-edge science-based functional ingredients. AZNPbio is a San Diego, California (CA) based, privately-held bio-tech company engaged in natural product sourcing, collection, extraction, purification and manufacturing to serve health product company’s ever-growing new target and ingredient developments. We have operations and collaborations in US and China. Our library includes more than 8000 bio-collections from over 3500 genera. Currently 5000 extracts purified from 3000 plant species, and 7000 HPLC-isolated compounds and fractions are ready for bio-active screening. One-third of our collections have origin from the Middle East and Africa. With samples derived from lichen, liverwort, fern, algae, mushroom, aquatics, marine, worm, higher plants and insects for bio-screening (HTS), generating hit-to-lead and preclinical candidates; AZNPbio can help grow your R&D pipeline of new drugs, cosmetics, preservatives, natural flavors, herbcides and pesticides.
Views: 172 Jeff Zhao
Zhendong Jin Associate Professor PhD
 
01:06
Dr. Jin researches the total synthesis of biologically active natural products & structural analogues, development of new synthetic methods with interest in asymmetric reactions, & synthesis of small libraries with the aim of anticancer drug discovery.
Views: 501 MNPCUI
Joshua Pierce CoBRAS
 
01:09:14
Joshua Pierce from NC State University presented a talk at the October 28, 2016 entitled "Marine Natural Products Synthesis: A Platform for Chemical and Biological Discovery" Abstract: Marine natural products often have complex structures and potent biological activities; however, little is understood regarding how their molecular structure correlates with function or what biological targets or pathways are involved. Through rapid and efficient chemical syntheses of bioactive marine natural products, we are able to prepare ample quantities of material to explore both structure-activity relationships as well as target identification studies. Specifically, the monanchocidin and synoxazolidinone families of natural products will be discussed, leading to novel synthetic derivatives that serve as lead structures for infectious disease and cancer chemical probe and therapeutic development.
7 Partial and Total Synthesis ch3 12th
 
06:12
https://youtu.be/J38wIFmH26w https://youtu.be/J38wIFmH26w https://youtu.be/J38wIFmH26w
Lecture 17
 
28:55
Application of Oxidative Cyclization in Natural Product Synthesis
Microwave Synthesis in Action
 
08:50
The new Milestone synthesis product line overcomes the limitation of conventional microwave synthesis devices, as it consists of a single microwave platform that, in combination with specific accessories, allows the chemists to perform classic glassware and high-pressure synthesis, as well as solid-phase reactions.
Synthesis Organic Compounds CHEM Study
 
20:24
Synthesis Organic Compounds 2nd Edition CHEM Study The Chemical Education Material Study, better known as CHEM Study, was developed in the early 1960s at U.C. Berkeley's College of Chemistry, Lawrence Hall of Science, and Harvey Mudd College, and continued at the Lawrence Hall of Science through the 1980s. The textbook was written by Glenn T. Seaborg in the early 1960s.
Partial and Total Synthesis
 
06:12
Chemistry_c-9-10-org-chem-68.mp4
Views: 3004 Sabaq. Pk
What is ORGANIC SYNTHESIS? What does ORGANIC SYNTHESIS mean? ORGANIC SYNTHESIS meaning & explanation
 
06:15
What is ORGANIC SYNTHESIS? What does ORGANIC SYNTHESIS mean? ORGANIC SYNTHESIS meaning - ORGANIC SYNTHESIS definition - ORGANIC SYNTHESIS explanation. Source: Wikipedia.org article, adapted under https://creativecommons.org/licenses/by-sa/3.0/ license. Organic synthesis is a special branch of chemical synthesis and is concerned with the construction of organic compounds via organic reactions. Organic molecules often contain a higher level of complexity than purely inorganic compounds, so that the synthesis of organic compounds has developed into one of the most important branches of organic chemistry. There are several main areas of research within the general area of organic synthesis: total synthesis, semisynthesis, and methodology. A total synthesis is the complete chemical synthesis of complex organic molecules from simple, commercially available (petrochemical) or natural precursors. Total synthesis may be accomplished either via a linear or convergent approach. In a linear synthesis—often adequate for simple structures—several steps are performed one after another until the molecule is complete; the chemical compounds made in each step are called synthetic intermediates. For more complex molecules, a convergent synthetic approach may be preferable, one that involves individual preparation of several "pieces" (key intermediates), which are then combined to form the desired product. Robert Burns Woodward, who received the 1965 Nobel Prize for Chemistry for several total syntheses (e.g., his 1954 synthesis of strychnine), is regarded as the father of modern organic synthesis. Some latter-day examples include Wender's, Holton's, Nicolaou's, and Danishefsky's total syntheses of the anti-cancer therapeutic, paclitaxel (trade name, Taxol). Each step of a synthesis involves a chemical reaction, and reagents and conditions for each of these reactions must be designed to give an adequate yield of pure product, with as little work as possible. A method may already exist in the literature for making one of the early synthetic intermediates, and this method will usually be used rather than an effort to "reinvent the wheel". However, most intermediates are compounds that have never been made before, and these will normally be made using general methods developed by methodology researchers. To be useful, these methods need to give high yields, and to be reliable for a broad range of substrates. For practical applications, additional hurdles include industrial standards of safety and purity. Methodology research usually involves three main stages: discovery, optimisation, and studies of scope and limitations. The discovery requires extensive knowledge of and experience with chemical reactivities of appropriate reagents. Optimisation is a process in which one or two starting compounds are tested in the reaction under a wide variety of conditions of temperature, solvent, reaction time, etc., until the optimum conditions for product yield and purity are found. Finally, the researcher tries to extend the method to a broad range of different starting materials, to find the scope and limitations. Total syntheses (see above) are sometimes used to showcase the new methodology and demonstrate its value in a real-world application. Such applications involve major industries focused especially on polymers (and plastics) and pharmaceuticals.
Views: 1528 The Audiopedia
Organic Synthesis in the D'Souza lab
 
00:21
Graduate student Melissa briefly explains her research in Dr. Francis D'Souza's organic synthesis lab at the University of North Texas.
Views: 73 UNT Chemistry
Classics in Total Synthesis
 
00:22
Views: 15 Adam C
Thyroid Hormone Production
 
07:17
http://www.handwrittentutorials.com - This tutorial takes a look at the production of thyroid hormones in the Thyroid Gland. This includes the transport of iodine and the production of thyroglobulin in the Thyroid Follicles. For more entirely FREE tutorials and accompanying PDFs visit http://www.handwrittentutorials.com
Views: 310628 Handwritten Tutorials
Advanced Higher: General Synthetic Pathways
 
11:47
This video is a series of examples of synthetic pathways. For each synthetic pathway you are to give the name of the type of reaction, reagents required and mechanism where known.
Views: 1239 Miss Adams Chemistry
Transitioning Organic Synthesis from Organic Solvents to Water
 
46:18
Dr. Bruce H. Lipshutz, Professor of Chemistry, University of California - Santa Barbara, discusses his work on developing an alternative to organic solvents that is safer and generates less waste. Learn how reactions can be carried out in water, mostly at room temperature.
Views: 814 ACSGCInstitute
Total synthesis of solanoeclepin A; Rosa  Marie Noy
 
03:14
Video Presentation of a scientific paper (AGRC1020) Animal Biology
Views: 156 Rosa- Marie Noy
Disconnection approach for normal to large carbocyclic rings
 
15:10
Subject:Chemistry Paper: Organic chemistry- IV (Advanced Organic Synthesis, supramolecular chemistry and carbocyclic rings)
Views: 208 Vidya-mitra

Here!
Kucanice sa prevodom online dating
Here!
Online dating questions you must ask on interview
Here!